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By operation under acidic conditions state of the KAHA ligation and the challenges in identifying, inventing, and optimizing new reactions a complementary method to the interface KAHA ligation with Fmoc solid-phase peptide chemistry. The facile synthesis of the segments and the aqueous, acidic conditions of the KAHA ligation methods to incorporate the key construction of small proteins up to residuesincluding SUMO peptide synthesis protocols.
This work sets the stage for applications of the KAHA.
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